Chemical Composition and Anti-acetylcholinesterase Activity of Flower Essential Oils of Artemisia annua at Different Flowering Stage

نویسندگان

  • Bochu Wang Bioengineering College of Chongqing University, Chongqing, 400044, P.R.China
  • Fumei Yang Drug Screening Lab, Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Science, 550001, P.R.China
  • Liancai Zhu Bioengineering College of Chongqing University, Chongqing, 400044, P.R.China
  • Qianyun Sunc Drug Screening Lab, Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Science, 550001, P.R.China
  • Zhannan Yang Zhannan Yang Guizhou Provincial Laboratory for Mountainous Environment (GLE), Guizhou Normal University, Guiyang, Guizhou 550001, P.R.China.
  • Zhengwen Yu Bioengineering College of Chongqing University, Chongqing, 400044, P.R.China. Life Science College of Guizhou Normal University, Guiyang, Guizhou, 550001, P.R.China
چکیده مقاله:

The chemical composition of the essential oils of flower at the pre-flowering, full-flowering and post-flowering stage of A. annua was analyzed by GC and GC/MS and sixty-two components were identified. The main compounds in the pre-flowering oil were β-myrcene (37.71%), 1, 8-cineole (16.11%) and camphor (14.97%). The full-flowering oil contained predominantly caryophyllene (19.4%), germacrene D (18.1%), camphor (15.84%), 1, 8-cineole (10.6%) and (Z)-β-farnesene (9.43%). The major constituents identified in the post-flowering oil were camphor (16.62%), caryophyllene (16.27%), β-caryophyllene oxide (15.84%), β-farnesene (9.05%) and (-)-spathulenol (7.21%). The variety of anti-AChE activity of flower oil of A. annua at three flowering stage might be a result of the variety of the content and interaction of those terpenoids with anti-AChE activity. The greatest acetylcholinesterase inhibitory activity (IC50 = 0.13 ± 0.02 mg mL-1) was exhibited by the essential oil of flower of A. annua at post-flowering stage.

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chemical composition and anti-acetylcholinesterase activity of flower essential oils of artemisia annua at different flowering stage

the chemical composition of the essential oils of flower at the pre-flowering, full-flowering and post-flowering stage of a. annua was analyzed by gc and gc/ms and sixty-two components were identified. the main compounds in the pre-flowering oil were β-myrcene (37.71%), 1, 8-cineole (16.11%) and camphor (14.97%). the full-flowering oil contained predominantly caryophyllene (19.4%), germacrene d...

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Chemical Compositionand Anti-acetyl cholinesterase Activity of Flower Essential Oils of Artemisiaannuaat Different Flowering Stage

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عنوان ژورنال

دوره Volume 10  شماره Number 2

صفحات  265- 271

تاریخ انتشار 2011-03-09

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